METAMATS_BURDEN

This Matlab software is a minimal code for fitting simultaneously primary tumor growth and metastatic burden data using nonlinear mixed-effects modeling [1].

Purpose

• Fit simultaneously data of primary tumor (PT) growth and metastatic burden (MB)
• Uses a deterministic model without secondary dissemination based on a convolution formula for the metastatic burden
• Nonlinear mixed-effects modeling (NLME, using Matlab function nlmefitsa, SAEM algorithm)
• Allows different units for PT and MB
• Plots the visual predictive check based on simulation of the population recovered from the NLME fit

How to use it

• Dependencies: carcinom, metamats_core
• Data provided by an excel file
• Loaded in import_data
• Models defined in build_models_met_PT
• Fit launched in launch_fit_met_PT_SAEM
• Simulation plotted in manips_plot_fit_met_PT_SAEM

[1] Benzekry, S., Tracz, A., Mastri, M., Corbelli, R., Barbolosi, D., & Ebos, J. M. L. (2016). Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach. Cancer Research, 76(3), 535–547. http://doi.org/10.1158/0008-5472.CAN-15-1389