Selected publications

Mathematical modeling of tumor-tumor distant interactions supports a systemic anti-proliferative control of tumor growth
S. Benzekry, C. Lamont, D. Barbolosi, L. Hlatky, P. Hahnfeldt
Cancer Research, 10.1158/0008-5472.CAN-17-0564, 2017


Modeling spontaneous metastasis following surgery: an in vivo-in silico approach
S. Benzekry, A. Tracz, M. Mastri, R. Corbelli, D. Barbolosi, J.M.L. Ebos
Cancer Research, Volume 76, Issue 3, pp. 535-547, 10.1158/0008-5472.CAN-15-1389, 2016


Classical Mathematical Models for Description and Forecast of Preclinical Tumor Growth
S. Benzekry, C. Lamont, A. Beheshti, A. Tracz, J.M.L. Ebos, L. Hlatky, P. Hahnfeldt
PloS Computational Biology, Volume 10, Issue 8, e1003800, 2014


Computational modelling of metastasis development in renal cell carcinoma
E. Baratchart, S. Benzekry*, A. Bikfalvi*, T. Colin*, L.S. Cooley, R. Pineau, E. Ribot, O. Saut, W. Souleyreau, * = joint supervising authors
PloS Computational Biology, Volume 11, Issue 11, e1004626, hal, 2015


Model Driven Optimization of Antiangiogenics + Cytotoxics Combination: Application to Breast Cancer Mice Treated with Bevacizumab + Paclitaxel Doublet Leads to Reduced Tumor Growth and Fewer Metastasis
S. Mollard, J. Ciccolini, D.C. Imbs, R. El Cheikh, D. Barbolosi, S. Benzekry
Oncotarget, Volume 5, 10.18632/oncotarget.15484, 2017


All publications

2017


29. Mathematical modeling of tumor-tumor distant interactions supports a systemic control of tumor growth
S. Benzekry, C. Lamont, D. Barbolosi, L. Hlatky, P. Hahnfeldt
Cancer Research, 10.1158/0008-5472.CAN-17-0564, 2017


28. Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach
M. Benguigui, D. Alishekevitz, M. Timaner, D. Shechter, Z. Raviv, S. Benzekry*, Y. Shaked*, * = joint supervising authors
submitted, 2017


27. Revisiting bevacizumab + cytotoxics scheduling using mathematical modeling: proof of concept study in experimental non-small cell lung carcinoma
D.C. Imbs*, R. El Cheikh*, A. Boyer, J. Ciccolini, C. Mascaux, B. Lacarelle, F. Barlesi, D. Barbolosi and S. Benzekry, * = equal contribution
submitted, 2017


26. Pharmacokinetics of nanoparticles in oncology: clues for anticipating interpatient variability
R. Fanciullino, S. Benzekry, B. Lacarelle, J. Ciccolini, A. Rodallec
submitted, 2017


25. Non-Standard Radiotherapy Fractionations Delay the Time to Malignant Transformation of Low-Grade Gliomas
A. Henares-Molina, S. Benzekry, P.C. Lara, M. Garcia-Rojo, V.M. Perez-Garcia and A. Martinez-Gonzalez
PloS One, Volume 12, Issue 6, e0178552, hal, 2017


24. Model Driven Optimization of Antiangiogenics + Cytotoxics Combination: Application to Breast Cancer Mice Treated with Bevacizumab + Paclitaxel Doublet Leads to Reduced Tumor Growth and Fewer Metastasis
S. Mollard, J. Ciccolini, D.C. Imbs, R. El Cheikh, D. Barbolosi, S. Benzekry
Oncotarget, Volume 5, 10.18632/oncotarget.15484, 2017


2016


23. Les lois de la croissance tumorale
S. Benzekry
Bibliothèque Tangente, Hors-série Maths et Médecine, 2016


22. In vivo bioluminescence tomography for monitoring breast tumor growth and metastatic spreading: comparative study and mathematical modeling
S. Mollard, R. Fanciullino, S. Giacometti, C. Serdjebi, S. Benzekry, J. Ciccolini
Nature Scientific Reports, Volume 6, pp.36173, 2016


21. Mathematical modeling of cancer immunotherapy and synergy with radiotherapy
R. Serre, S. Benzekry, L. Padovani, C. Meille, N. André, J. Ciccolini, F. Barlési, X. Muracciole, and D. Barbolosi
Cancer Research, Volume 76, Issue 17, pp. 4931–40, 10.1158/0008-5472.CAN-15-3567, 2016


20. Modeling spontaneous metastasis following surgery: an in vivo-in silico approach
S. Benzekry, A. Tracz, M. Mastri, R. Corbelli, D. Barbolosi, J.M.L. Ebos
Cancer Research, Volume 76, Issue 3, pp. 535-547, 10.1158/0008-5472.CAN-15-1389, 2016


19. Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6–8 May 2016, Mumbai.
Pantziarka, P., Hutchinson, L., André, N., Benzekry, S., Bertolini, F., Bhattacharjee, A., et al.
ecancermedicalscience, 10, 2016


2015


18. Computational modelling of metastasis development in renal cell carcinoma
E. Baratchart, S. Benzekry*, A. Bikfalvi*, T. Colin*, L.S. Cooley, R. Pineau, E. Ribot, O. Saut, W. Souleyreau, * = joint supervising authors
PloS Computational Biology, Volume 11, Issue 11, e1004626, hal, 2015


17. Metronomics reloaded: theoretical models bringing chemotherapy into the era of precision medicine
S. Benzekry+, E. Pasquier+, D. Barbolosi, B. Lacarelle, F. Barlesi, N. Andre and J. Ciccolini
Seminars in Cancer Biology, Volume 35, pp. 53-61, 10.1016/j.semcancer.2015.09.002, 2015


16. Improving efficacy of the combination between antiangiogenic and chemotherapy: Time for mathematical modeling support
J. Ciccolini, S. Benzekry, B. Lacarelle, D. Barbolosi and F. Barlési
Proc Natl Acad Sci USA, Volume 112, Issue 27, 10.1073/pnas.1506689112, 2015


15. Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth
S. Benzekry, A. Beheshti, P. Hahnfeldt, L. Hlatky
bio-protocol, Volume 5, Issue 21, e1644, hal, 2015


14. On the growth and dissemination laws in a mathematical model of metastatic growth
S. Benzekry, J. ML Ebos
ITM Web of Conferences, Volume 5, 10.1051/itmconf/20150500007, 2015


13. Design Principles for Cancer Therapy guided by changes in complexity of Protein-Protein Interaction Networks
S. Benzekry , J.A. Tuszynski, E.A. Rietman, G.L. Klement
Biology Direct, Volume 10, Issue 32, 2015


12. Host Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression
A. Beheshti, S. Benzekry, J.T. MacDonald, L. Ma, M. Peluso, P. Hahnfeldt, L. Hlatky
Cancer Research, Volume 75, Issue 6, pp. 1134-43, 2015


2014


11. Classical Mathematical Models for Description and Forecast of Preclinical Tumor Growth
S. Benzekry, C. Lamont, A. Beheshti, A. Tracz, J.M.L. Ebos, L. Hlatky, P. Hahnfeldt
PloS Computational Biology, Volume 10, Issue 8, e1003800, 2014


10. Global Dormancy of Metastases due to Systemic Inhibition of Angiogenesis
S. Benzekry, A. Gandolfi, P. Hahnfeldt
PloS One, Volume 9, Issue 1, e84249, 2014


9. A mathematical model of systemic inhibition of angiogenesis in metastatic development
S. Benzekry, A. Gandolfi, P. Hahnfeldt
ESAIM: Proceedings, Volume 45, pp. 75-87, 2014


8. A Mathematical Model for Growing Metastases on Oncologists’s Service
D. Barbolosi, A. Benabdallah, S. Benzekry, J. Ciccolini, C. Faivre, F. Hubert, F. Verga, B. You
In Computational Surgery and Dual Training, Springer New York, pp. 331-338, 2014


2013


7. Maximum Tolerated Dose Versus Metronomic Scheduling in the Treatment of Metastatic Cancers
S. Benzekry, P. Hahnfeldt
Journal of Theoretical Biology, Volume 335, pp. 235-244, 2013


Quantitative analysis of the tumor/metastasis system and its optimal therapeutic control
S. Benzekry, D. Barbolosi, A. Benadballah, F. Hubert and P. Hahnfeldt
2013


6. Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice
F. Lignet, S. Benzekry, S. Wilson, F. Billy, O. Saut, M. Tod, B. You, A. Adda Berkane, S. Kassour, M.X. Wei, E. Grenier, B. Ribba
Journal of Theoretical Biology, Volume 320, pp. 86-99, 2013


2012


5. Modelling the impact of anticancer agents on metastatic spreading
S. Benzekry, N. André, A. Benabdallah, J. Ciccolini, C. Faivre, F. Hubert and D. Barbolosi
Mathematical Modeling of Natural Phenomena , Volume 7, Issue 1, pp. 306 - 336, 2012


4. A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology
S. Benzekry, G. Chapuisat, J. Ciccolini, A. Erlinger and F. Hubert
Comptes Rendus de l'Académie des Sciences - Mathématiques, Volume 350, Issue 1-2, pp. 23-28, 2012


3. Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers
S. Benzekry
ESAIM: Mathematical Modelling and Numerical Analysis, Volume 46, Issue 2, pp. 207-237, 2012.


2011


2. Passing to the limit 2D-1D in a model for metastatic growth
S. Benzekry
Journal of Biological Dynamics, Volume 6, Suppl. Issue 1, pp. 19-30, 2011


1. Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis,
S. Benzekry
Journal of Evolution Equations Volume 11, Issue 1, pp. 187-213, 2011


Foreign research visits

Fall 2016. Short sabbatical at the Roswell Park Cancer Institute to work with John ML Ebos, Buffalo, NY, USA.

September 2015. Invited researcher in the Môlab to work with Alicia Martinez-Gonzalez and Victor Pérez-Garcia, Ciudad Real, Spain.

January 2012 - November 2012. Postdoc at the Center of Cancer and Systems Biology, Boston, USA.

May 2011. Instituto di Analisi dei Sistemi ed Informatica ''Antonio Ruberti'', Consiglio Nazionale delle Ricerche. Research visit with Alberto Gandolfi and collaboration with Alberto d'Onofrio, from the European Institute of Oncology from Milan. Rome, Italy.

March - June 2007. Master 2’s intership in the mathematical department of the Polytechnical University of Catalonia : Exploration of deterministics and stochastics neuronal reds. Barcelona, Spain.


Invited talks and seminars

May 2017, Laboratoire d'Analyse Topologie et Probabilites, Institut de Mathematiques de Marseille. Mathematical Oncology: Theory Meets Reality. Marseille, France.

November 2016, Integrated Mathematical Oncology Department, Moffitt Cancer Center.Mathematical Modeling of Metastasis: Theory Meets Reality. Tampa, Florida, USA.

October 2016, Department of Genetics, Roswell Park Cancer Institute (invitation by John ML Ebos). Mathematical Modeling of Metastasis: Theory Meets Reality. Buffalo, NY, USA.

October 2016, Robert Kerbel's laboratory at Sunnybrook Research Institute. Mathematical Modeling of Metastasis: Theory Meets Reality. Toronto, Canada.

October 2016, Mathematics Department Colloquium, Ryerson University. Mathematical Modeling of Metastasis: Predicting the invisible. Toronto, Canada.

May 2016, Metronomics @ Mumbai. Mathematical modeling of chemotherapy scheduling. Mumbai, India.

May 2016, Seminar at the laboratory of Génétique, Immunothérapie, Chimie et Cancer of the University of Tours. Data-based mathematical modeling analysis of preclinical studies in oncology. Tours, France.

January 2016, Seminar at the laboratoire d'imagerie biomédicale. Classical Mathematical Models for Description and Prediction of Experimental Tumor Growth. Paris, France.

December 2015, Present challenges of mathematics in oncology and biology of cancer. Marseille, France.

November 2015, Dynamique et contrôle des croissances tumorales, Rouen, France.

November 2015, Contrôle des EDP et applications , Marseille, France.

October 2015, Journées du Groupe de Métabolisme et Pharmacocinétique , Paris, France.

June 2015, Micro and Macro Systems in Life Sciences (MMSLS 2015), Bedlewo, Poland.

March 2015, Workshop on hybrid and multiscale modelling in cell and cell population biology , Laboratoire Jacques-Louis Lions. Combined in vivo and in silico quantitative modeling of post-surgery metastatic development. Paris, France.

March 2015, Mathematical Methods and Modeling of Biophysical Phenomena, Cabo Frio, Rio de Janeiro, Brazil.

January 2015, 36th EORTC PAMM Winter meeting , Marseille, France.

October 2014, Autumn School by Japanese and French Mathmaticians . Mathematical modeling of tumor growth and metastatic spread. Data, theories and predictions. Osaka, Japan.

July 2014, 10th AIMS Conference on Dynamical Systems, Differential Equations and Applications . A mathematical model of systemic inhibition of angiogenesis in metastatic development. Madrid, Spain.

March 2014, Seminar at the inria team Dracula. Classical Mathematical Models for Description and Prediction of Experimental Tumor Growth. Lyon, France.

January 2014, Seminar at the ISPED. Classical Mathematical Models for Description and Forecast of Preclinical Tumor Growth. Bordeaux, France.

November 2013, French-Mexican Meeting on Industrial and Applied Mathematics, Villahermosa, México. Classical Mathematical Models for Description and Forecast of Preclinical Tumor Growth

May 2013, Bi-annual congress of the SMAI. Mathematical modeling of systemic inhibition of angiogenesis and metastatic dynamics. Seignosse, France.

April 2013, Seminar of the ANEDP team . Mathematical modeling of systemic inhibition of angiogenesis and metastatic dynamics. Orsay, France.

March 2013, Workshop on Mathematical Methods and Modeling of Biophysical Phenomena, Cabo Frio, Brazil. Mathematical modeling of systemic inhibition of angiogenesis and metastatic dynamics

February 2013, Seminar of the LATP, Marseille, France. A math walk in a biology lab

July 2012, 2nd Annual Workshop on Cancer Systems Biology — Tumor Metronomics: Timing and Dose Level Dynamics, Center for Cancer and Systems Biology, Boston. Mathematical modeling of metastatic development and scheduling optimization of anti-cancerous therapies

March 2012, Thematic school : "Present challenges of mathematics in oncology and biology of cancer", CIRM, Marseille. A modeling approach for therapies in metastatic cancers

November 2011, EDP seminar of the mathematics lab in Besançon. Modélisation et analyse mathématique de thérapies anti-cancéreuses pour les cancers métastatiques

October 2011, Journées du Groupe de Métabolisme et Pharmacocinétique. Paris. Poster and Oral communication, Biomathematical modeling for description of metastatic processes and optimization of combined anti-angiogenic + cytotoxic therapies.

July 2011, Workshop on Systems Biology of Tumor Dormancy. St. Elizabeth's Medical Center, Boston USA. A modelling approach for therapies in metastatic cancers.

July 2011, 7th Congrès International Congress on Industrial and Applied Mathematics - ICIAM 2011, Vancouver. Mathematical modeling of the metastatic process and optimization of anti-cancerous therapies.

May 2011. Seminar at the Instituto di Analisi dei Sistemi ed Informatica ``Antonio Ruberti'', Rome. A modelling approach for the metastatic process.

May 2011. ``Emergence'' day of the Institut Gustave Roussy (IGR).Un exemple de modélisation du processus métastatique. Paris, France.

June 2010, CANUM 2010. A model of metastatic growth under angiogenic control. Gironde, France. May 2010, AIMS Dresde. Modeling and mathematical analysis of metastatic growth under angiogenic control. Dresden, Germany

May 2010, Seminar Maths-Bio of the university Lyon 1. Modeling and mathematical analysis of metastatic growth under angiogenic control. Lyon, France

March 2010, 2nd Workshop on Metronomic Anti-Angiogenic Chemotherapy in Paediatric Oncology. Mathematical modeling of MTD and metronomic temozolomide. Marseille, France.

Accepted oral communications

March 2016, 38th EORTC-PAMM Winter meeting, Split, Croatia. Optimization of the timing of sequential administration of bevacizumab plus cytotoxics in NSCLC by a mathematical model.

October 2015, Journées du cancéropôle Grand Sud-Ouest , Bordeaux, France. Poster. Modeling spontaneous metastasis following surgery: an in vivo-in silico approach

June 2015, Mathematical Methods in Systems Biology, Dublin, Ireland.

June 2014, European Conference on Mathematical and Theoretical Biology , Göteborg, Sweden. Metastatic dynamics, systemic inhibition of angiogenesis and implications for surgery

June 2014, International Tumor Dormancy Symposium , Lille, France. Metastatic dynamics and systemic inhibition of angiogenesis. Implications for dormancy and surgery (Poster)

February 2014, Demonstration during the inria-industry meeting, Lyon, France. Mathematical Models in Preclinical Cancer Research

June 2011, 8th European Conference on Mathematical and Theoretical Biology - ECMTB 2011 and Annual Meeting of The Society for Mathematical Biology, Kraków. Optimal schedules for therapies in metastatic cancers .

May 2010, CMPD 3, Bordeaux. Modeling and mathematical analysis of metastatic growth under angiogenic control.

November 2009, Conference of biomathematics et biomechanics, Tozeur, Tunisie. Presentation of a poster.

August 2009, CEMRACS. Asymptotic behavior of the solutions of the renewal equation and Angiogenesis modeling.

June 2009. Bucolic days of the student's seminar of the LATP.

November 2008, Workgroup Maths-Cancer of Marseille. About the article "A theoretical study of the response of vascular tumours to different types of chemotherapy" de J. Panovska, H. M. Byrne et P. K. Maini.


Participation to conferences and summer schools

6-8 June 2011, Biomat 2011, Perspectives in Mathematics and Life Sciences.

3-4 Février 2011, Journées Louis Antoine "Nonlocal equations and population adaptive dynamics".

2 December 2010. Thematic day "Models and imaging in oncology", Paris, France.

30 November - 1er December 2009. Symposium "Health and complex systems" of the Entretiens Jacques Cartier, Lyon, France.

20-23 November 2009. Conference of biomathématics et biomechanics, Tozeur, Tunisie.

20 July - 28 August 2009. CEMRACS'09 Mathematical modeling in Medicine. Project Angio. CIRM, Marseille, France.

2 - 13 February 2009. Advanced courses and conferences in mathematical biology : modeling and differential equations. CRM, Barcelone, Espagne.

18 - 19 December 2008. Pharmacokinetics and pharmacodynamics of anticancerous drugs : resistances and synergies. Centre de recherche des cordeliers, Paris.